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Annuaire


LUCA GRUMOLATO


MAITRE DE CONFERENCES

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Tél : +33 2 35 14 66 40
Fax : +33(0)235146946
luca.grumolato@univ-rouen.fr



INSERM U982-IRIB Place E. Blondel 76821 Mont-Saint-Aignan
DEPARTEMENT DE BIOLOGIE
DIFFERENCIATION ET COMMUNICATION NEURONALE ET NEUROENDOCRINE
-Maître de Conférences (Associate Professor)

Thèmes de recherche

Our group focuses on the molecular mechanisms and the biological implications of signaling pathway activation in cancer. The evolution of multicellular organisms has involved the development of intercellular communication required for processes such as embryonic development, tissue differentiation, and systemic responses to wounds and infections. These complex signaling networks are in large part mediated by growth factors, cytokines and hormones. In normal conditions, such factors can influence cell proliferation in positive or negative ways, as well as induce a series of differentiated responses in appropriate target cells. Present knowledge indicates that the constitutive activation of signaling pathways through different mechanisms contributes to the development and progression of most if not all human cancers. Major Projects: 1) Based on CRISPR/Cas9 technology, we have recently devised a new approach to recapitulate cancer evolution through the emergence of new mutations in a context of intratumor heterogeneity. Among the different potential applications, this strategy, which we named CRISPR-barcoding, can be implemented to model multiple mechanisms of drug resistance or to repair oncogenic driver mutations in addicted cancer cells. We are currently using CRISPR-barcoding and other more conventional approaches to devise new therapeutic strategies to prevent non-small cell lung cancer resistance to EGFR inhibitors. 2) We investigate the role of canonical and noncanonical Wnt signaling and ROR1/2 receptors in two types of neuroendocrine tumors derived from the sympathoadrenal lineage: neuroblastoma and pheochromocytoma/paraganglioma. Current members: Luca Grumolato (Associate Professor), David Alexandre (Associate Professor), Alexis Guernet (Ph.D. Student), Sylvain Lesne (Ph.D. Student) ************************************************ POSTDOCTORAL POSITION AVAILABLE

CV

Master in Molecular Biology (1999), University of Torino, Italy

Ph.D. in Cell Biology (2004), University of Rouen, France (Supervisor: Dr Y. Anouar)

Post-Doctoral Fellow (2004-2010), Department of Oncological Sciences, Mount Sinai School of Medicine, New York, USA (Dr S.A. Aaronson's lab)

Instructor (2011), Department of Oncological Sciences, Mount Sinai School of Medicine, New York, USA (Dr S.A. Aaronson's lab)

Maître de Conférence (Associate Professor; 2011-present)

Chair of Excellence INSERM-University of Rouen (2011-16), Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, INSERM U982, Mont Saint Aignan, France

Informations Complémentaires

Funding:

Ligue contre le Cancer, Fondation ARC, ANR, INCa

Selected Publications:

Guernet A. and Grumolato L. (2017) CRISPR/Cas9 editing of the genome for cancer modeling. Methods 121-122: 130-137

Guernet A., Mungamuri S.K., Cartier D., Sachidanandam R., Jayaprakash A., Adriouch S., Vezain M., Charbonnier F., Rohkin G., Coutant S., Yao S., Ainani H., Alexandre D., Tournier I., Boyer O., Aaronson S.A., Anouar Y. and Grumolato L. (2016) CRISPR-Barcoding for Intratumor Genetic Heterogeneity Modeling and Functional Analysis of Oncogenic Driver Mutations. Mol. Cell 63:526-38

Mungamuri S.K., Murk W., Grumolato L., Bernstein E. and Aaronson S.A. (2013) Chromatin Modifications Sequentially Enhance ErbB2 Expression in ErbB2-Positive Breast Cancers. Cell Reports S2211-1247(13)00517-2. 10.1016/j.celrep.2013.09.009.

Serysheva E., Berhane H., Grumolato L., Demir K., Balmer S., Bodak M., Boutros M., Aaronson S., Mlodzik M. and Jenny A. (2013) Wnk kinases are positive regulators of canonical Wnt/β-catenin signalling. EMBO Reports 14:718-25

Grumolato L., Liu G., Haremaki T., Mungamuri S.K., Mong P., Akiri G., Lopez-Bergami P., Arita A., Anouar Y., Mlodzik M., Ronai Z.A., Brody J., Weinstein D.C. and Aaronson S.A. (2013) β-Catenin-independent activation of TCF1/LEF1 in human hematopoietic tumor cells through interaction with ATF2 transcription factors. PLoS Genetics 9: e1003603 1.

Vijayakumar S. Liu G., Rus I.A.,Yao S., Chen Y., Akiri G., Grumolato L. and Aaronson S.A. (2011) Upregulated autocrine Wnt signaling drives proliferation of multiple human sarcoma subtypes through a novel TCF/-catenin target gene, CDC25A. Cancer Cell 19:601-12

Grumolato L., Liu G., Mong P., Mudbhary R., Biswas R., Arroyave R., Vijayakumar S., Economides A.N. and Aaronson S.A. (2010) Canonical and noncanonical Wnts utilize a common mechanism to activate completely unrelated co-receptors. Genes Dev 24:2517-30

Asciutti S., Akiri G., Grumolato L., Vijayakumar S. and Aaronson S.A. (2011) Diverse mechanisms of Wnt activation and effects of pathway inhibition on proliferation of human gastric carcinoma cells. Oncogene 30:956-66. Epub 2010 Nov 1

 








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