M. Victor NORRIS
|Discipline||Biochimie et biologie moléculaire|
|Corps||Professeur des universites|
|Fonction(s)||Director of Theoretical Biology Unit|
Deputy Director of the Epigenomics Project, Genopole, Evry
Member of the Centre Interdisciplinaire de Biologie Intégrative
Member of the scientific board of the Fondation Fourmentin-Guilbert
Member of the Faculty of a 1000
|Affectation||Ufr sciences techniq - dpt biologie|
|Bureau||M111 Guy de la Brosse (Batiment de Mat)|
|Tél||+33 2 35 52 29 75|
|Integrative approaches to the bacterial cell cycle|
Thèmes de recherche
|How do cells choose a few coherent, reproducible phenotypes out of the hyper-astronomical number apparently available to them? Trying to answer this question as theoretical biologist with integrative tendencies, has led me to develop new biological concepts such as competitive coherence, organisation at the level of hyperstructures, and Life on the Scales. My collaborators and I use these concepts to tackle other, related questions about the control and the function of the cell cycle, the marriage between metabolism and signalling, and the origins of life. We use a variety of approaches from mathematics and programming complemented by experiments based on Secondary Ion Mass Spectrometry. Spin-offs of our hypotheses include new techniques for bacterial and viral therapies, for studying phenotypic diversity at the level of single cells, for analysing individual DNA molecules and the molecules that associate with them, for biology-based computing, and perhaps even for a 'PCR of proteins'. In many of my activities, I try to act as a 'catalyst' within and across the disciplines and this has led me to collaborate with a couple of hundred scientists over the years.|
Born 1st August 1948 in the UK. British nationality. Married with two children. Qualifications include a degree in Psychology (University of Manchester), Biology and Mathematics (Open University), D.E.A. in Microbiology (Institut de Genetique et Microbiologie, Orsay), and a Ph.D on the termination of DNA replication in E. coli (Institut Jacques Monod). Periods of employment include working as a mathematics lecturer in Libya and as a computer engineer with I.C.L. followed by research as a postdoctoral research associate and independent fellow in the University of Leicester (1986-1996) where I set up a group to study the cell cycle of the bacterium Escherichia coli and its relationship with calcium and eukaryotic-like protein phosphorylation. I also set up the Laboratory of Theoretical Biology to bring together biologists, physicists and mathematicians to study fundamental problems in biology such as the origin of life. In 1996, I became Professor of Integrative Biology in the Université de Rouen and in 2002 coordinator of the Epigenomics Programme in Genopole, Evry. My interests include developing the concept of hyperstructures as an intermediate level of organisation in cells via (1) interdisciplinary projects aimed at an integrative modelling of the biological cell using a variety of concepts and techniques from physical chemistry, computer science and physics and (2) the technique of Secondary Ion Mass Spectrometry. I have published more than a 180 scientific articles in refereed journals, I am a regular reviewer for a score of journals and I organise numerous conferences including the annual "Modelling and simulation of biological processes in the context of genomics".
|Recent Awards: Winner with Annabelle Merieau of the Elie Wollman Challenge 2009, an international competition organised by the Pasteur Institute.|
Selected recent publications
Poyer, F., Coquerel, B., Pegahi, R., Cazin, L., Norris, V., Vannier, J.-P. and Lamacz, M. 2009. Secretion of MMP-2 and MMP-9 induced by VEGF autocrine loop correlates with clinical prognosis in childhood acute lymphoblastic leukemia (ALL). Leukemia Research 3: 407-417.
Norris, V., Bresson-Dumont, H., Gardea, E., Reusch, R.N. and Gruber, D. 2009 Hypothesis: Poly-(R)-3-hydroxybutyrate is a major factor in intra-ocular pressure. Medical Hypotheses 73: 398-401
Thierry, A., Norris, V., Molina, F. and Schmutz, M. 2009 Lipoplex nanostructures reveal a general auto-organization of nucleic acids. Biochim Biophys Acta 1790: 385-394.
Norris, V. and Root-Bernstein, R. 2009 Review: the eukaryotic cell originated in the integration and redistribution of hyperstructures from communities of prokaryotic cells based on molecular complementarity. Int. J. Mol. Sci. 10: 2611-2632.
Legent, G. and Norris, V. 2009 Hybolites: novel therapeutic tools for targeting hyperstructures in bacteria. Recent Patents on anti-Infective Drug Discovery, 4: 90-95.
Norris, V. and Grondin, Y. 2010 QUESTION 8: is life an emergent property? Origins of Life and Evolution of Biospheres, 40: 386-391.
Cabin-Flaman, A., A.F. Monnier, Y. Coffinier, J.N. Audinot, D. Gibouin, T. Wirtz, R. Boukherroub, H.N. Migeon, A. Bensimon, L. Janniere, C. Ripoll, and V. Norris, Combed Single DNA Molecules Imaged by Secondary Ion Mass Spectrometry. Anal Chem, 2011. 83(18): p. 6940-6947.
Guzmán, E., I. Salguero, C. Mata Martín, E. López-Acedo, E. Guarino Almeida, M. Sánchez-Romero, V. Norris, and A. Jiménez-Sánchez, Relationship between fork progression and initiation of chromosome replication in E. coli., in DNA Replication, H. Seligmann, Editor. 2011, InTech: Rijeka, Croatia. p. 203-220.
Norris, V., Speculations on the initiation of chromosome replication in Escherichia coli: The dualism hypothesis. Med Hypotheses, 2011. 76(5): p. 706-16.
Norris, V. and Y. Grondin, DNA movies and panspermia. Life, 2011. 1: p. 9-18.
Norris, V., A. Zemirline, P. Amar, J.N. Audinot, P. Ballet, E. Ben-Jacob, G. Bernot, G. Beslon, A. Cabin, E. Fanchon, J.L. Giavitto, N. Glade, P. Greussay, Y. Grondin, J.A. Foster, G. Hutzler, J. Jost, F. Kepes, O. Michel, F. Molina, J. Signorini, P. Stano, and A.R. Thierry, Computing with bacterial constituents, cells and populations: from bioputing to bactoputing. Theory Biosci, 2011. 130(3): p. 211-28.
Norris, V. and Y. Grondin, Making bacteriophage DNA into a movie for panspermia. Journal of Cosmology, 2011. 16: p. 7158-7176.
Norris, V., M. Engel, and M. Demarty, Modelling biological systems with competitive coherence. Advances in Artificial Neural Systems, 2012. 2012: p. 1-20.
Fishov, I. and V. Norris, Membrane structure and heterogeneity., in Escherichia coll and Bacillus subtilis; the frontiers of molecular microbiology revisited., Y. Sadaie and K. Matsumoto, Editors. 2012, Research Signpost: Kerala, India. p. 93-113.
Norris, V., L. Menu-Bouaouiche, J.-M. Becu, R. Legendre, R. Norman, and J.A. Rosenzweig, Hyperstructure interactions influence the virulence of the Type 3 secretion system in yersiniae and other bacteria. Appl Microbiol Biotechnol, 2012. 96: 23-36.
Fishov, I. and V. Norris, Membrane domains and DNA replication. Curr Opin Microbiol, 2012, 15:724-30.
Norris, V. and P. Amar, Replication in Escherichia coli: Life on the scales. Life, 2012. 2: p. 286-312.
Norris, V., A. Thierry, P. Amar, and F. Molina, The Mimic Chain Reaction. J Mol Microbiol Biotechnol, 2012, 22:335-43.
Norris, V., C. Loutelier-Bourhis, and A. Thierry, How did Metabolism and Genetic Replication Get Married? Orig Life Evol Biosph, 2012, 42:487-9.
Norris, V., F. Molina, and A.T. Gewirtz, Hypothesis: bacteria control host appetites. Journal of Bacteriology, 2013, 195(3):411-6.
Norris, V., P. Amar, G. Legent, C. Ripoll, M. Thellier, and J. Ovadi, Hypothesis: the cytoskeleton is a metabolic sensor. BMC Biochemistry, 2013, 14:3.
Norris, V., Hyperstructures, in Encyclopedia of Sciences and Religions, N.P. Azari, A., Runehov, and L. Oviedo, Editors. 2013, Springer. in press.
Norris, V., Competitive coherence, in Encyclopedia of Sciences and Religions, N.P. Azari, A. Runehov, and L. Oviedo, Editors. 2013, Springer. in press.
Ovadi, J. and V. Norris, Moonlighting function of the tubulin cytoskeleton: macromolecular architectures in the cytoplasm, in Systems biology of metabolic and signaling networks: energy, mass and information transfer, M. Aon, V. Saks, and U. Schlattner, Editors. 2013, Springer. in press.
Cabin-Flaman, A., A.-F. Monnier-Batto, Y. Coffinier, J.-N. Audinot, D. Gibouin, T. Wirtz, R. Boukherroub, H.-N. Migeon, A. Bensimon, L. Jannière, C. Ripoll, and V. Norris, DNA combing and Secondary Ion Mass Spectrometry. Methods in Molecular Biology, Protein Blotting and Detection, 2013: in press.
Thellier, M., V. Norris, and C. Ripoll, Memory processes in the control of plant growth and morphogenesis. Nova Acta Leopoldina, 2013, 114:21-42.
Norris, V. and A. Merieau, Plasmids as scribbling pads for operon formation. Res Microbiol, 2013: in press.
Norris, V., C. Verrier, and P. Schneider, Hybolites revisited. Acta Biotheor, 2013: invited.
Norris, V., Scientific English: clear enough is good enough. 2013, Trends in Microbiology, 21:503-504.
Norris, V., G. Gangwe Nana, and J.-N. Audinot, New approaches to the problem of generating coherent, reproducible phenotypes. Theor Biosci, 2013: in press.
Hamid, N., Monnier, A-F., Fossum-Raunehaug, S., Maciag-Dorszynska, M., Cabin-Flaman, A., Képès, F., Wegrzyn, G., Norris, V., Szalewska-Palasz, A., Skarstad, K., Jannière, L. Control of DNA replication by central carbon metabolism in Bacillus subtilis. J Mol Biol, 2013: submitted.
Norris, V., C. Ripoll, G. Legent, A. Delaune, and G. Misevic, Method for biomolecule detection and quantification at the cell single level using secondary ion mass spectrometry, US 61/035,803, 2008: USA
Norris, V., C. Ripoll, G. Legent, G. Misevic, and A. Delaune, Improved method for a highly sensitive detection and quantification of biomolecules using secondary ion mass spectrometry (SIMS) and related technologies, EP09305855.0, 2009: Europe.
plus 4 enveloppes Soleau